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1.
Enferm Clin (Engl Ed) ; 32 Suppl 1: S54-S63, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35094968

RESUMO

OBJECTIVE: To determine the validity of the five-level TRIPED-GM pediatric triage system. METHODS: Unicentric, observational, descriptive, cross-sectional study of 485 patients aged 0-16 years in the pediatric emergency department of the HGU Gregorio Marañon. Two measures of validity were used: a direct measure calculated by the sensitivity and specificity obtained based on the number of infratriages and overtriages of the priorities given by classification nurses compared with a panel of experts and another indirect measure by the length of stay, the resources consumed and the percentage of income for each priority level. RESULTS: 10 patients were incorrectly classified, 4 (0.8%) were considered infratriages and 6 (1.2%) overtriages. The results showed a sensitivity of 99.45% (95% CI 96.5-99.97%) and a specificity of 99.01% (95% CI 96.9-99.7%) for high priorities (P2 and P3) and 98.99% (95% CI 96.8-99.6%) and 98.4% (95% CI 96.84-99.74%) respectively for low priorities (P4 and P5). The quadratic weighted Kappa index was 0.96 (95% CI 0.94-0.98; p = 0.0000). Resource consumption showed moderate Spearman correlation coefficients as the priority level increased. The percentage of admissions and the need for observation increased as the priority level p = 0,000 increased, not requiring observation or admitting any patients with priority 5. CONCLUSIONS: The TRIPED-GM pediatric triage system is valid for use in emergency departments with similar patients.


Assuntos
Serviço Hospitalar de Emergência , Triagem , Criança , Estudos Transversais , Hospitalização , Humanos , Sensibilidade e Especificidade
2.
Rev. fitoter ; 12(2): 101-116, dic. 2012. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-110321

RESUMO

La actividad antipatotóxica del fruto de cardo mariano y de la silimarina es conocida desde hace muchos años. Su efecto positivo sobre el hígado está basado en las acciones antioxidante, estabilizadora de membrana, favorecedora de la síntesis proteica, antivirásica, antiinflamatoria, inmunomoduladora y anticolestásica de la silimarina y su principal componente, la silibinina. Su eficacia clínica ha sido demostrada en distintos tipos de alteraciones hepáticas, principalmente en las producidas por alcohol y las causadas po virus. Diversos estudios han establecido el papel quimiopreventivo de la silimarina y de la silibinina en distintas áreas celulares cancerosas, así como su efecto estimulante sobre la secreción láctea, además de su actuación en otros ámbitos (protección ósea, neuroprotección, aterogénesis, etc.). a este conjunto de datos, que apuntan hacia posibles nuevas aplicaciones de los productos obtenidos a partir del cardo mariano, se une su amplio margen terapéutico y su baja toxicidad (AU)


Antihepatotoxic activity of milk thistle fruit and silymarin has been known for many years. The positive effect on the liver is based on the antioxidant, membrane stabilizing, protein synthesis increase, antiviral, anti-inflammatory, immunomodulatory and anticolestatic actions of sylimarin and its major constituten, silybinin. Its clinical efficacy has been shown in several types for liver disorders, namely those produced by alcohol and those caused by virus. Several studies have established the chemopreventive role of sylimarin and silybinin in different cancer cell lines and its stimulating effect on lactation, as well as their beneficial effects in other areas (bone protection, neuroprotection, atherogenesis,e tc.). All these data point to possible new applications of the products derived from milk thistle that, in addition, show a wide therapeutic range and low toxicity (AU)


Assuntos
Humanos , Masculino , Feminino , Cardo-Mariano/química , Cardo-Mariano/imunologia , Cardo-Mariano/fisiologia , Silimarina/farmacologia , Silimarina/farmacocinética , Antioxidantes/uso terapêutico , Hepatite/terapia , Silimarina/uso terapêutico , Cirrose Hepática/terapia , Anti-Inflamatórios/uso terapêutico , Resultado do Tratamento , Avaliação de Eficácia-Efetividade de Intervenções
3.
Rev. fitoter ; 7(2): 131-151, jul.-dic. 2007. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-132767

RESUMO

El bulbo de ajo (Allium sativum L., Liliaceae) es empleado desde antiguo, además de en alimentación, con distintos fines terapéuticos, tales como el tratamiento de la hipertensión, procesos infecciosos, etc. En la actualidad, el interés científico por el bulbo de ajo se encuentra dirigido a validar su actuación en ámbitos de la salud tan relevantes como la enfermedad cardiovascular y los procesos cancerosos. Los numerosos estudios realizados hasta el momento han puesto de manifiesto la actuación de algunos de los preparados disponibles en el mercado (tabletas de ajo pulverizado, aceite de ajo obtenido mediante destilación, extractos acuosos e hidroalcohólicos, extracto de ajo envejecido (AGE), etc.) y de sus principales componentes, tanto en el tratamiento de los distintos factores implicados en la enfermedad cardiovascular como en algunos de los pasos del proceso canceroso. Además, se han demostrado los efectos antioxidantes y antimicrobianos de dichos preparados y de algunos de los principales componentes de los mismos (AU)


In addition to its use as food, garlic bulbs (Allium sativum L., Liliaceae) have been used since long time, for several therapeutic purposes, e.g.: treatment of hypertension and infectious processes. At present, the scientific interest on garlic is mainly directed to validate its activity on relevant health issues, as cardiovascular disease (CVD) and cancer. The numerous studies so far performed have shown the activity of some of the market-available products (garlic powder tablets, steam-distilled oil, aqueous and hydroalcoholic extracts, aged garlic extract (AGE), etc) and of their main constituents on the factors involved in CVD and cancer processes. Moreover, the antioxidant and antimicrobial effects of these preparations and some of their main constituents have been demonstrated (AU)


Assuntos
Humanos , Masculino , Feminino , 25939/uso terapêutico , Alho , Alho/imunologia , Hipertensão/terapia , Doenças Transmissíveis/terapia , Antioxidantes/uso terapêutico , Anti-Infecciosos/uso terapêutico , Doenças Cardiovasculares/terapia , Estresse Oxidativo , Pressão Arterial , Transtornos do Metabolismo dos Lipídeos/terapia
4.
Rev. fitoter ; 7(1): 5-12, ene.-jun. 2007. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-132684

RESUMO

El síndrome premenstrual (SPM) es un trastorno recurrente que aparece en la fase lútea del ciclo, caracterizado por la aparición de síntomas físicos (hinchazón abdominal o de las extremidades, tensión mamaria, cefaleas) y psicológicos (depresión, irritabilidad, ansiedad, fatiga). Afecta a más del 50% de las mujer es en la etapa reproductiva y , en una minoría de casos (3-5%), puede llegar a ser incapacitante. En su etiología intervienen diversos factor es, entre los que destacan los relacionados con distintos sistemas de neurotransmisión (sero-toninérgico, gabaérgico, dopaminérgico y opioide) así como la influencia que sobre los mismos ejercen las hormonas sexuales y sus metabolitos. Una de las posibilidades terapéuticas con las que se cuenta en el tratamiento del SPM son los preparados del fruto de sauzgatillo (Vitex agnus-castus L.), activos sobre los receptores D2 y opioides, y que han sido objeto de varios ensayos clínicos en los que se ha demostrado su efecto beneficioso sobre este síndrome (AU)


The Premenstrual Syndrome (PMS) is a recurrent disorder that occurs in the luteal phase of the menstrual cycle, characterised by symptoms both physical (abdominal bloating, breast swelling, headache) and psychological (depressed mood, irritability , anxiety, fatigue). It affects more than 50% of women in reproductive age, and, in a minority of cases (3-5%) can become disabling. Several factors are involved in its aetiology, the most outstanding among them being those related with several neurotransmitter systems (serotoninergic, gabaergic, dopaminer gic, and opioid), and the influence of sexual hormones and its metabolites on them. One of the therapeutic possibilities to consider in the treatment of PMS are the preparations obtained from the fruit of chaste tree (Vitex agnus-castus L.), which are active on brain D2 and opioid receptors, and have demonstrated efficacy on PMS in several clinical trials (AU)


Assuntos
Humanos , Feminino , Síndrome Pré-Menstrual/terapia , Vitex/imunologia , Mastodinia/terapia , Plantas Medicinais , Extratos Vegetais/uso terapêutico , Fitoterapia/instrumentação , Fitoterapia/métodos , Fitoterapia
5.
Psicothema (Oviedo) ; 19(2): 225-230, mayo 2007.
Artigo em Es | IBECS | ID: ibc-054876

RESUMO

Este trabajo tiene como objetivo analizar el modo en que distintos factores de riesgo psicosocial en el trabajo pueden ser indicativos del mobbing en una muestra de 638 trabajadores, 168 hombres y 470 mujeres del sector hortofrutícola. Se administró un cuestionario anónimo a todos los empleados que estaban presentes en las empresas que componen la muestra el día de la evaluación de riesgos psicosociales. Después de analizar los datos proporcionados por la escala de mobbing NAQ-RE (Sáez, García-Izquierdo, y Llor, 2003), y por los del método de evaluación de factores de riesgo psicosocial del INSHT (Martín y Pérez, 1997), podemos destacar que mediante un análisis de correlación canónica aparece que ciertos factores psicosociales como definición de rol, carga mental, interés por el trabajador y supervisión / participación, predicen dos de las formas de mobbing: acoso personal y acoso centrado en el rendimiento del trabajo


This work analyses the way in which va-rious psychosocial risk indicators may predict mobbing. A sample of 638 workers, 168 men and 470 women, from the fruit-and-vegetable sector was evaluated. An anonymous questionnaire was administered to all employees who were present on the evaluation days in the companies comprising the study. After analysing the data obtained with the mobbing questionnaire NAQ-RE (Sáez, García-Izquierdo, & Llor, 2003) and with the psychosocial risk factors evaluation method of the INSHT (Martín & Pérez, 1997), using canonical regression, we found that several psychosocial factors such as role definition, mental workload, interest in the workers, and supervision / participation predict two types of mobbing: personal mobbing and work-performance-related mobbing


Assuntos
Masculino , Feminino , Humanos , Comportamento Social , Agressão , Carência Psicossocial , Inquéritos e Questionários , 16360 , 16359 , Fatores de Risco , Valor Preditivo dos Testes
6.
Rev. fitoter ; 5(2): 149-152, dic. 2005. ilus, tab, graf
Artigo em Es | IBECS | ID: ibc-051271

RESUMO

Los bulbos de ajo (Allium satívum), uno de los principales ingredientes de la cocina española, se emplean desde antiguo con fines terapéuticos, muchos de ellos validados científicamente, como es el caso de su empleo como biocida. En el presente trabajo se ha estudiado la actuación in vitro frente a larvas L3 de Anisakis simplex s.l. de los sobrenadantes de licuados de A. sativum (cultivar morado), obtenidos tanto de bulbos recién recolectados (T1) como tras seis (T2) y doce meses (T3) de la recolección. Los resultados muestran que los sobrenadantes más activos son los correspondientes a T2, con una mortalidad del 100% de las larvas. Los componentes implicados en esta actividad parecen ser el disulfuro y el trisulfuro de dialilo junto con otro derivado azufrado no identificado


The garlic bulbs (Allium sativum), one of the main ingredients of the Spanish cuisine, are employed since ancient times for therapeutic purposes, many of which are now scientifically validated, as it is the case of its use as biocide. In the present study we have established the in vitro activity against Anisakis simplex s.l. L3 larvae of the supernatants of A. sativum (purple cultivar) liquates obtained from bulbs recently collected (TI) or after six (T2) and twelve (T3) months of the harvesting. The results show that the more active supernatant is the corresponding to with a 100% of larvae mortality. The compounds invalved this activity seem to be diallyl disulphide and diallyl trisulphide along with another unidentified sulphured compound


Assuntos
Animais , Anisakis , Larva , Alho , Testes de Sensibilidade Parasitária
7.
Planta Med ; 69(5): 472-4, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12802735

RESUMO

We investigated the effect of maslinic acid (a triterpene derivative obtained from olive pomace), on the susceptibility of plasma or hepatocyte membranes to lipid peroxidation (LPO), induced respectively by the hydroxyl radical (OH*) generated by Fe2+/H2O2 ex vivo and by the system Fe3+/ascorbate in vitro; moreover, three groups of animals used in the plasma study were pretreated with CCl4 (to generate CCl3-*). Endogenous plasma lipoperoxide levels and susceptibility to LPO were decreased in rats treated with maslinic acid, after exposure to OH* by Fe2+/H2O2 (Fenton reaction). Co-incubation with maslinic acid prevented hepatocyte membrane LPO as shown by the reduction of TBARS. In conclusion, maslinic acid may offer some advantages in the resistance of oxidative stress in the animals.


Assuntos
Antioxidantes/farmacologia , Peroxidação de Lipídeos/efeitos dos fármacos , Olea , Fitoterapia , Triterpenos/farmacologia , Animais , Antioxidantes/administração & dosagem , Antioxidantes/uso terapêutico , Tetracloreto de Carbono , Feminino , Hepatócitos/efeitos dos fármacos , Peróxidos Lipídicos/metabolismo , Extratos Vegetais/administração & dosagem , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Triterpenos/administração & dosagem , Triterpenos/uso terapêutico
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